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The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of <t>smartphone</t> camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.
Smartphone Cameras, supplied by Xiaomi Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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smartphone camera  (Xiaomi Inc)
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Xiaomi Inc smartphone camera
The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of <t>smartphone</t> camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.
Smartphone Camera, supplied by Xiaomi Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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item details hardware smartphone camera xiaomi 12t pro  (Xiaomi Inc)
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Xiaomi Inc item details hardware smartphone camera xiaomi 12t pro
The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of <t>smartphone</t> camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.
Item Details Hardware Smartphone Camera Xiaomi 12t Pro, supplied by Xiaomi Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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12t pro smartphone camera  (Xiaomi Inc)
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The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of <t>smartphone</t> camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.
12t Pro Smartphone Camera, supplied by Xiaomi Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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xiaomi smartphone camera data  (Xiaomi Inc)
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The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of <t>smartphone</t> camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.
Xiaomi Smartphone Camera Data, supplied by Xiaomi Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of smartphone camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.

Journal: medRxiv

Article Title: CLIA MDK: A Modular Smartphone Platform Matching Plate Reader Performance for Chemiluminescent Immunoassay Development

doi: 10.64898/2026.03.26.26348440

Figure Lengend Snippet: The effect of image acquisition and processing on the lower limit of detection (LLoD), limit of quantification (LoQ), and upper limit of detection (ULoD) on two CLIAs quantified with MR and X13P. a Average spectral response of smartphone camera sensors in blue (line), green (line), and red (line) channels (data taken form ) with Luminol emission spectrum (black line) and its peak and center wavelength (vertical dotted dashed line and dashed line). b Primary color channel-based dynamic range for a renin assay at different concentrations with the average signal (black dot, vertical line (mean ± SD), n = 2) normalized to the LLoD (vertical orange line) with LoQ (vertical violet line), ULoD (vertical pink line) and sensor saturation (vertical dashed red line, at 16-bit). The grey box indicates the range between LLoD and ULoD. The further apart the data and limits, the larger the dynamic range. c Same as in b with the green channel and different ISO values (1600, 3200, 12800). d Same as in b with the green channel, ISO 1600 for different exposure times (t exp = 5, 15, 30 s). e Same as in b with the green channel, ISO = 1600, t exp = 5 s for unprocessed (RAW), ROF denoising (ROF), NREA on RAW or ROF denoised images (NREA RAW , NREA ROF ) for one and a series of six images. f Standard curve for renin for RAW (dark blue dots, vertical bar, mean ± SD), and NREA ROF (light blue dots, vertical bar, mean ± SD) with LLoD, LoQ, and ULoD (vertical orange, violet, and pink line, dotted RAW, solid NREA ROF ). The inset shows the zoomed-in region between 0 and 50 pg mL −1 , visualizing the improvement in sensitivity of NREA ROF between 0 and 10 pg mL −1 compared to the other condition. g Same as in f for the standard curve of the aldosterone assay.

Article Snippet: We evaluated smartphone cameras (Xiaomi 13 Pro, Huawei P60 Pro, P20, Fairphone 5, Nokia G22) and CSI cameras (Arducam 3MP, 5MP, OmniVision 5640) for low-cost, high-sensitivity CLIA applications.

Techniques: